Metabolic control in integrated biochemical systems
نویسندگان
چکیده
منابع مشابه
A comparison of variant theories of intact biochemical systems. II. Flux-oriented and metabolic control theories.
In the past two decades, several theories, all ultimately based upon the same power-law formalism, have been proposed to relate the behavior of intact biochemical systems to the properties of their underlying determinants. Confusion concerning the relatedness of these alternatives has become acute because the implications of these theories have never been compared. In the preceding paper we cha...
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The claim by Savageau et al. (1987 a, b, Math. Biosci. 86, 127-145, 147-167) that the theory of metabolic control associated with Kacser & Burns (1973, Symp. Soc. Exp. Biol. 27, 65-104) and with Heinrich & Rapoport (1974, Eur. J. Biochem. 42, 89-102) is no more than a special case of the biochemical systems theory of Savageau and colleagues is examined. It is shown to be based on a misconceptio...
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Perhaps the major obstacle to recognizing the relatedness of Biochemical Systems Theory (BST) and a subsequently developed approach some have called Metabolic Control Theory (MCT) is the summation and connectivity relationships. These are the most visible and central features of the MCT approach to the understanding of intact hiochcmical systems. whereas in the BST approach they appear to he in...
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Biochemical Systems Theorv (BST) was developed in the late 1960s to explicate the integrated behavior of intact biochemical systems-specific dynamic behavior as well as general principles of design-in relation to the properties of their underlying molecular elements. This approach was used successfully in a number of biochemical and other biological applications throughout the 1970s and 1980s. ...
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1. The ability of exogenously administered cyclic AMP (adenosine 3': 5'-monophosphate) to exert andromimetic action on certain carbohydrate-metabolizing enzymes was investigated in the rat prostate gland and seminal vesicles. 2. Cyclic AMP, when injected concurrently with theophylline, produced marked increases in hexokinase, phosphofructokinase, glyceraldehyde phosphate dehydrogenase, pyruvate...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2002
ISSN: 0014-2956
DOI: 10.1046/j.1432-1033.2002.03088.x